The methylation cycle:
We are living in exciting times when new knowledge of epigenetics is opening doors to disease prevention and management. We can no longer trust “one size fits all” protocols. We must address each individual’s unique genetics and exposures to create a bioindiviualized programs. Epigenetics is a breakthrough in how we address disease and emotional dysfunction!
Methylation is a process critical for creating and maintaining DNA and new cells. It involves adding chemicals called “methyl groups” to proteins, DNA and other molecules. Methylation is important for the entire life process. It affects detox, aging, and survival. Dysfunction in methylation affects new cell synthesis which can contribute to autoimmunity. When genes are not methylated it can trick the immune system into reacting against itself.
Individuals with genetic methylation mutations have difficulty making regulatory T cells. T cells help the body control the B cells and prevent autoimmune antibodies. If you are not making adequate T cells, then you may end up with auto immune antibodies. Methylation also plays a role in the ability of the immune system to recognize foreign bodies. If it does not recognize foreign bodies, it cannot respond to them. In this way, assisting the function of the methylation cycle could be a key in managing autoimmune disease.
SAMe (S-adenosyl methionine) is the most active methyl donor in the body. If we don’t have enough SAMe or if it cannot be recycled properly, we can see issues of neurotransmitter imbalance, difficulty with detoxification, issues with the formation of myelin surrounding the nerves and cellular energy generation.